In keeping with HIV-NAT’s desire to expand into other fields of study, currently there are 7 studies looking at various issues ranging from asthma to immunology to adherence. All of the studies are currently ongoing. One of the study looks at asthma while two investigate the immune response and another surveillancing HIV drug resistance and its new recombinant forms. One study examines voluntary counselling and testing (VCT) among MSMs whereas two other studies investigate adherence in adolescents and TB co-infected patients respectively. Other studies are being developed with experts from the geriatric, psychiatric and molecular biology departments as well as community non-governmental organizations (NGOs).
HIV-NAT is interested in other areas of study and is always looking for collaborators and/or partners to share this with. However, HIV-NAT also understands the need to prioritize its work so each year, certain areas are chosen to be further investigated. There are many ideas for studies but for now, only those studies that can address the current needs of HIV-NAT patients and Thailand will be put into motion.
Asthma - Children with HIV and Asthma (CHIVAS)
Allergen specific T effector and T regulatory cell response to common aeroallergens following immune restoration in HIV-infected children
This aims to study allergen specific T effector and T regulatory cell response in HIV-infected children before and after commencement of HAART.
Immunology studies - CD4+poor response
Prevalence, factors and immunopathogenesis of inappropriate immune reconstitution (CD4+ below 200 cells/mm3) in Thai patients with long term viral suppression following antiretroviral therapy.
This is a retrospective, observational study that addresses why some HIV patients have CD4 <200 copies/mm3 despite being on ART and have viral load <50 copies/mL. This study will assess the factors contributing to this phenomenon and how these patients differ compared to those with CD4 <200 copies/mm3.
This is a prospective, observational study to explore reconstitution of immunity in patients with advanced HIV-1-infection commencing combination antiretroviral therapy. The protocol is designed to mirror standard of care (SOC) visits for this patient population. The main difference to SOC is the formal collection of data and the collection of extra blood volumes.
Multidisciplinary services to enhance HIV testing and linkage to care among MSM
This is a prospective cohort study which will determine the impact of MSM-targeted multidisciplinary services on uptake of HIV voluntary counseling and testing (VCT) and enrollment into care and retention of HIV-positive MSM.
Drug Resistance - HIV Drug Resistance Study
Surveillance of HIV resistance transmission and new HIV recombinant forms in Thailand
Adherence study - TApHOD ACASI
The objective of this study is to collect information on adherence and behavioral risk factors in HIV-infected adolescents who are being followed in the TApHOD cohort study.
Questionnaire study - Adherence, associated factors and interventions (TB questionnaire study)
Causes of discontinuity of tuberculosis treatment and strategies to improve the treatment outcomes of tuberculosis in University Hospital
The objective of this study is survey of tuberculosis in Bangkok will begin university hospital and new patient to find of cause of absence of drug and loss follow up of treatment in the Chulalongkorn hospital, for the reflect problem of tuberculosis in the big cities.
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The HIV Netherlands Australia Thailand Research Collaboration