There are 6 pharmacokinetic studies, 3 of which are done in children and 2 in adolescents. All of the pediatric pharmacokinetic (PK) studies are ongoing. One adult pharmacokinetic study was completed in 2012. The manuscript for this study was drafted at the time this annual report was published (December 2012).
“HIV-NAT is a pioneer in studying PK of antiretrovirals in Thai patients. HIV-NAT’s studies have shed light on the uniqueness in PK and pharmacogenomic profile of Asians. HIV-NAT studies have consistently shown that Thais have high NNRTI and PI drug concentrations compared to those reported in Caucasians. This has led to changes in the Thai national guideline to use lower than manufacturer-recommended dosages for several antiretroviral drugs.Using low dose antiretrovirals could lead to reduce side effects and cost; an important consideration for resource-limited settings such as Thailand. ”– Sasiwimol Ubolyam
Therapeutic Drug Monitoring (TDM) Studies
Therapeutic Drug Monitoring of the generic tenofovir/lamivudine/efavirenz tablets in the Thai HIV-infected Patient
This is a prospective, open-label, single arm study that assesses the efficacy and safety of fixed dose combination of TDF/3TC/EFV.
Pharmacokinetics Study of Tenofovir in HIV-infected Thai Children using Tenofovir-based Regimen
This study will assess the pharmacokinetics of Tenofovir in HIV-infected Thai children using Tenofovir-based regimen.
TDF PK in adolscents
The objective of this study is to describe the PK parameters of TDF when administered with PIs in HIV-infected Asian adolescent aged 12-<18 years
TDF PK in adolscents
The objective of this study is to describe mid-dose concentration of TDF in children aged 8 - <18 years using TDF in various dosages
The study of atazavanir/ritonavir-based HAART in Thai HIV-infected children
This trial will study the pharmacokinetics of atazanavir/ritonavir (ATV/r) in HIV-1 infected Thai children.
Pharmacokinetics of Abacavir once daily vs. twice daily in HIV-infected Thai Children
This study will evaluate pharmacokinetic of abacavir in Thai HIV-infected children.
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The HIV Netherlands Australia Thailand Research Collaboration