Project no.: HIV-NAT 232/Frailty
This is a cross-sectional study examining the prevalence rate and determinants of frailty in the HIV positive and negative Thai populations
Results: A total of 324 HIV-positive and 131 HIV-negative controls aged > 50 years were enrolled, 37.0% were females with a mean (SD) age of 56.0 (5.5) years and 32.6% were females with a mean (SD) age of 58.3 (5.8) years, respectively. HIV-positive subjects were on cART for a mean duration of 15.2 (4.5) years. Comorbidity prevalence in the HIV-positive group was: hypertension 36.7%, hyperlipidemia 34.0%, diabetes 15.1%, renal dysfunction 7.1%, hepatitis B 13.0%, and hepatitis C 4.4%, and cardiovascular disease 2.2%. Pre-frailty (62.0% vs. 46.2%) (P ≤ 0.005), and frailty (6.5% vs. 1.5%) were more prevalent in the HIV-positive group as was the case for each of the five domains. In multivariable analysis, factors associated with frailty were HIV status (OR 2.04, 95%CI 1.24-3.35, P < 0.005) and female gender (OR 3.97, 95% CI 2.36-6.67, P < 0.001). In the analysis of HIV-positive subjects only, of the sociodemographic, HIV-related, and comorbidity-related covariates, only hypertension (OR 2.40, 95% CI 1.32-4.35, P < 0.004) was significantly associated with frailty.
(Source: Do T, et al., Frailty is Associated with HIV and Female Sex in Asians 0ver 50. Abstract # TUPEB134. Presented at AIDS Conference 2018)