{"id":1855,"date":"2018-12-31T00:00:13","date_gmt":"2018-12-30T17:00:13","guid":{"rendered":"https:\/\/www.hivnat.org\/en\/?p=1855"},"modified":"2022-03-30T11:08:34","modified_gmt":"2022-03-30T04:08:34","slug":"a-phase-iii-randomized-open-label-controlled-trial-to-investigate-the-efficacy-and-safety-of-ub-421-monotherapy-as-substitution-for-stable-antiretroviral-therapy-in-hiv-1-infected-adults","status":"publish","type":"post","link":"https:\/\/www.hivnat.org\/en\/studies\/1855\/","title":{"rendered":"A phase 3, randomized, open-label, controlled trial to investigate the efficacy and safety of UB-421 monotherapy as substitution for stable antiretroviral therapy in HIV-1 infected adults"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">This is an open-label, Phase III study to evaluate the efficacy, safety and tolerability of UB-421 monotherapy in suppressing viral rebound while replace HAART in virally suppressed HIV-1 infected adults. In this study, approximately 375 subjects on stable HAART treatment will be randomized to receive either continuing HAART treatment alone (Cohort 1) or UB-421 as the monotherapy (Cohort 2) in 1:2 ratio. For Cohort 1, subjects will receive current standard HAART treatment as the active control group. For Cohort 2, UB-421 will be administered to enrolled subjects without HAART treatment in the Cohort 2 during the 26-week treatment period. After treatment period, both cohort 1 and cohort 2 enter 22-week follow-up period.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\t\t\t\tDescription: n\/a\t\t<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[],"class_list":["post-1855","post","type-post","status-publish","format-standard","hentry","category-studies"],"_links":{"self":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts\/1855","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/comments?post=1855"}],"version-history":[{"count":2,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts\/1855\/revisions"}],"predecessor-version":[{"id":3484,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts\/1855\/revisions\/3484"}],"wp:attachment":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/media?parent=1855"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/categories?post=1855"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/tags?post=1855"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}