{"id":1867,"date":"2018-12-31T00:00:10","date_gmt":"2018-12-30T17:00:10","guid":{"rendered":"https:\/\/www.hivnat.org\/en\/?p=1867"},"modified":"2018-12-31T00:00:10","modified_gmt":"2018-12-30T17:00:10","slug":"effect-of-calcium-and-high-dose-vitamin-d-supplementation-on-bone-mineral-density-among-prenatally-hiv-infected-children-and-adolescents-cal-d","status":"publish","type":"post","link":"https:\/\/www.hivnat.org\/en\/studies\/1867\/","title":{"rendered":"Effect of calcium and high-dose vitamin D supplementation on bone mineral density among prenatally HIV-infected children and adolescents (CAL-D)"},"content":{"rendered":"\n\t\t\t\t\n<p class=\"wp-block-paragraph\"><strong>Project no.: <\/strong>HIV-NAT 225<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This study is a multicenter, randomized,\nopen-labeled, phase II clinical trial comparing the effect of a 48-week daily\ncalcium and high-dose vitamin D supplementation to calcium plus normal dose\nvitamin D supplementation on bone mineral density (BMD) in perinatally HIV\ninfected children and adolescents. <strong><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Brief Summary: <\/strong>The benefits of calcium and vitamin D\nsupplementation for low bone mass remains controversial. This study assessed\nthe changes in bone mineral density (BMD) during periods without and with\ncalcium and vitamin D supplementation among HIV-infected adolescents with low\nBMD.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Perinatally HIV-infected Thai adolescents aged 12-20 years were enrolled into Phase 1 (pre-supplementation) to evaluate longitudinal change of BMD. We provided education about appropriate dietary intake and exercise. Lumbar spine (L2-L4) BMD and vitamin D status (25-hydroxyvitamin D [25(OH)D]) were assessed at baseline and at 12-24 month intervals. Participants with a BMD Z-score \u2264 -2 were enrolled into Phase 2 (supplementation) that provided calcium 600 mg plus cholecalciferol 200 IU twice daily for 6 months. BMD and 25(OH)D were re-assessed at the end of study. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ninety-four participants were enrolled into the Phase I Median age (IQR) was 14.3 (13.0-15.5) years, with 67% at Tanner stage 3-5, 89% with a plasma HIV-1 RNA &lt; 50 copies\/mL. During Phase 1 and a 22.7-month follow-up, median L2-L4 BMD Z-scores remained unchanged (-1.06 <em>vs<\/em>\u00a0-1.08,\u00a0<em>P<\/em> = 0.08), but 25(OH)D levels increased (24.7 <em>vs<\/em>\u00a026.7\u00a0ng\/mL,\u00a0<em>P<\/em> = 0.01). Twenty-six (28%) adolescents had low BMD and were enrolled into Phase II with 24 (92%) completing follow-up. The median L2-L4 BMD Z-scores (-2.59 <em>vs<\/em>\u00a0-1.70;\u00a0<em>P<\/em> &lt; 0.001) and calcium level (9.3 <em>vs<\/em>\u00a09.5\u00a0mg\/dL,\u00a0<em>P<\/em> = 0.04) significantly improved. There was an increase in BMD Z-scores during the 6-months post-supplementation as compared to the 21-month pre-supplementation period (0.65 <em>vs<\/em>\u00a0-0.50,\u00a0<em>P<\/em> = 0.03). <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">HIV-infected adolescents with\nlow BMD had improved bone health after calcium and vitamin D supplementation. A\nrandomised controlled trial is warranted to confirm the benefits of these\nsupplements.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">(Source: Puthanakit T, et al., J Virus Erad.&nbsp;2018 Jan 1;4(1):6-11)<\/p>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\t\t\t\tThis study is a multicenter, randomized, open-labeled, phase II clinical trial comparing the effect of a 48-week daily calcium and high-dose vitamin D supplementation to calcium plus normal dose vitamin D supplementation on bone mineral density (BMD) in perinatally HIV infected children and adolescents. \t\t<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[],"class_list":["post-1867","post","type-post","status-publish","format-standard","hentry","category-studies"],"_links":{"self":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts\/1867","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/comments?post=1867"}],"version-history":[{"count":0,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts\/1867\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/media?parent=1867"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/categories?post=1867"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/tags?post=1867"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}