{"id":1869,"date":"2018-12-31T00:00:46","date_gmt":"2018-12-30T17:00:46","guid":{"rendered":"https:\/\/www.hivnat.org\/en\/?p=1869"},"modified":"2018-12-31T00:00:46","modified_gmt":"2018-12-30T17:00:46","slug":"human-papillomavirus-infection-in-perinatally-hiv-infected-adolescents-in-asia","status":"publish","type":"post","link":"https:\/\/www.hivnat.org\/en\/studies\/1869\/","title":{"rendered":"Human papillomavirus infection in perinatally HIV-infected adolescents in Asia"},"content":{"rendered":"\n\t\t\t\t\n<p><strong>Project no.: <\/strong>HIV-NAT 185\/TA008\/HPV study<\/p>\n\n\n\n<p>This is a longitudinal case-control study to monitor a cohort of perinatally HIV-infected and matched HIV-uninfected adolescent females and males between 12-24 years of age, for up to 156 weeks in three participating clinical sites in Thailand and two in Vietnam for HPV infection.<\/p>\n\n\n\n<p><strong>Brief Summary:<\/strong> Infection with high-risk human papillomavirus (HR-HPV) may be higher in perinatally human immunodeficiency virus (HIV)-infected (PHIV) than HIV-uninfected (HU) adolescents because of long-standing immune deficiency.<\/p>\n\n\n\n<p>PHIV\nand HU females aged 12-24 years in Thailand and Vietnam were matched by age\ngroup and lifetime sexual partners. At enrollment, blood, cervical, vaginal,\nanal, and oral samples were obtained for HPV-related testing. The Wilcoxon and\nFisher exact tests were used for univariate and logistic regression for\nmultivariate analyses.<\/p>\n\n\n\n<p>Ninety-three PHIV and 99 HU adolescents (median age 19 [18-20] years) were enrolled (June 2013-July 2015). Among PHIV, 94% were currently receiving antiretroviral therapy, median CD4 count was 593 (392-808) cells\/mm3, and 62% had a viral load &lt; 40 copies\/mL. Across anogenital compartments, PHIV had higher rates of any HPV detected (80% vs 60%; P = 0.003) and any HR-HPV (60% vs 43%, P = 0.02). Higher proportions of PHIV had abnormal Pap smears (eg, atypical squamous cells of unknown significance [ASC-US], 12% vs 14%; low-grade squamous intraepithelial neoplastic lesions, 19% vs 1%). After adjusting for ever being pregnant and asymptomatic sexually transmitted infections (STI) at enrollment, PHIV were more likely to have HR-HPV than HU (odds ratio, 2.02; 95% confidence interval, 1.09-3.77; P = 0.03).<\/p>\n\n\n\n<p>Perinatal\nHIV infection was associated with a higher risk of HR-HPV and abnormal cervical\ncytology. Our results underscore the need for HPV vaccination for PHIV\nadolescents and for prevention and screening programs for HPV and other STIs.<\/p>\n\n\n\n<p>(Source: Sohn AH, et al., Clin Infect Dis.&nbsp;2018 Aug 1;67(4):606-613)<\/p>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\t\t\t\tThis is a longitudinal case-control study to monitor a cohort of perinatally HIV-infected and matched HIV\u2013uninfected adolescent females and males between 12-24 years of age, for up to 156 weeks in three participating clinical sites in Thailand and two in Vietnam for HPV infection.\t\t<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[],"class_list":["post-1869","post","type-post","status-publish","format-standard","hentry","category-studies"],"_links":{"self":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts\/1869","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/comments?post=1869"}],"version-history":[{"count":0,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts\/1869\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/media?parent=1869"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/categories?post=1869"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/tags?post=1869"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}