{"id":2255,"date":"2014-12-31T00:00:49","date_gmt":"2014-12-30T17:00:49","guid":{"rendered":"https:\/\/www.hivnat.org\/en\/?p=2255"},"modified":"2014-12-31T00:00:49","modified_gmt":"2014-12-30T17:00:49","slug":"tenofovir-pharmacokinetics-in-hiv-infected-thai-adults-with-moderate-renal-function-impairment-receiving-either-a-non-nucleoside-reverse-transcriptase-inhibitor-nnrti-based-or-lopinavir-ritonavir-ba","status":"publish","type":"post","link":"https:\/\/www.hivnat.org\/en\/studies\/2255\/","title":{"rendered":"Tenofovir pharmacokinetics in HIV-infected Thai adults with moderate renal function impairment receiving either a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)-based or Lopinavir\/Ritonavir-based antiretroviral therapy"},"content":{"rendered":"\n\t\t\t\t\n<p class=\"wp-block-paragraph\"><strong>Project no.:<\/strong> HIV-NAT 172\/ALTER Study<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study is a phase I, non-randomized, open-label, pharmacokinetic study to evaluate the pharmacokinetics of tenofovir (TDF) in HIV-infected Thai adults with a creatinine clearance between 30 to &lt; 50mL\/min when administered at the recommended dose of 300 mg every 48 hours, and at an alternative dose of 150 mg every 24 hours, as part of a NNRTI-based HAART regimen or a lopinavir\/ritonavir-based HAART regimen.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Presentation:<\/strong> submitted to CROI 2015<\/p>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\t\t\t\tThe study is a phase I, non-randomized, open-label, pharmacokinetic study to evaluate the pharmacokinetics of tenofovir (TDF) in HIV-infected Thai adults with a creatinine clearance between 30 to < 50mL\/min when administered at the recommended dose of 300 mg every 48 hours, and at an alternative dose of 150 mg every 24 hours, as part of a NNRTI-based HAART regimen or a lopinavir\/ritonavir-based HAART regimen.\t\t\n<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[],"class_list":["post-2255","post","type-post","status-publish","format-standard","hentry","category-studies"],"_links":{"self":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts\/2255","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/comments?post=2255"}],"version-history":[{"count":0,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts\/2255\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/media?parent=2255"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/categories?post=2255"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/tags?post=2255"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}