{"id":2261,"date":"2014-12-31T00:00:54","date_gmt":"2014-12-30T17:00:54","guid":{"rendered":"https:\/\/www.hivnat.org\/en\/?p=2261"},"modified":"2014-12-31T00:00:54","modified_gmt":"2014-12-30T17:00:54","slug":"evaluation-of-novel-concepts-in-optimization-of-antiretroviral-efficacy-encore1","status":"publish","type":"post","link":"https:\/\/www.hivnat.org\/en\/studies\/2261\/","title":{"rendered":"Evaluation of Novel Concepts in Optimization of antiRetroviral Efficacy (ENCORE1)"},"content":{"rendered":"\n\t\t\t\t\n<p class=\"wp-block-paragraph\"><strong>Project no.:<\/strong> HIV-NAT 128<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A randomized, double-blind, placebo-controlled, clinical trial to compare the safety and efficacy of reduced dose (400mg) efavirenz (EFV) with standard dose EFV plus two nucleotide reverse transcriptase inhibitors (N(t)RTI) in antiretroviral-naive HIV-infected individuals over 96 weeks. HIV-NAT is the Thai co-ordinating centre. There are three substudies: 1) CNS, 2) Intensive PK and 3) Neurocognitive substudy. Staff from HIV-NAT have initiated this last substudy and will be responsible for the data collection and sub-study analysis. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Publications:<\/strong> <\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>J Antimicrobial Ther 2011; 66: 635\u201040<\/li><li>Lancet. 2014;383(9927):1474-82. <\/li><\/ol>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\t\t\t\tA randomized, double-blind, placebo-controlled, clinical trial to compare the safety and efficacy of reduced dose (400mg) efavirenz (EFV) with standard dose EFV plus two nucleotide reverse transcriptase inhibitors (N(t)RTI) in antiretroviral-naive HIV-infected individuals over 96 weeks.\t\t<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[],"class_list":["post-2261","post","type-post","status-publish","format-standard","hentry","category-studies"],"_links":{"self":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts\/2261","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/comments?post=2261"}],"version-history":[{"count":0,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts\/2261\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/media?parent=2261"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/categories?post=2261"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/tags?post=2261"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}