{"id":2291,"date":"2014-12-31T00:00:55","date_gmt":"2014-12-30T17:00:55","guid":{"rendered":"https:\/\/www.hivnat.org\/en\/?p=2291"},"modified":"2014-12-31T00:00:55","modified_gmt":"2014-12-30T17:00:55","slug":"penta-11","status":"publish","type":"post","link":"https:\/\/www.hivnat.org\/en\/studies\/2291\/","title":{"rendered":"PENTA 11"},"content":{"rendered":"\n\t\t\t\t\n<p class=\"wp-block-paragraph\"><strong>Project no.:<\/strong> HIV-NAT 066<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">PENTA 11 was an open, multicentre randomised phase II trial coordinated by PENTA to determine whether HIV-positive children are disadvantaged clinically, immunologically or virologically by CD4-driven planned treatment interruptions.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This pilot study enrolled chronically infected children aged 2 \u2013 15 years of age with suppressed HIV viral load and CD4% \u2265 30% (ages 2-6) or CD4% \u2265 25% and CD4 \u2265 500 cells\/mm<sup>3<\/sup> (ages 7 and over). After two years of follow-up post-trial, no adverse clinical, immunological or virological consequences of planned treatment interuptions were observed. The study was supported by PENTA, Great Ormond Street Children\u2019s Charity, and the European Union\u2019s 7<sup>th<\/sup> Framework Programme.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Publication:<\/strong> <\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Response to planned treatment interruptions in HIV infection varies across childhood. AIDS (London, England).\u00a0 2010 Jan 16;24(2):231-41.<\/li><li>Adherence to Antiretroviral Therapy and Acceptability of Planned Treatment Interruptions in HIV-Infected Children. AIDS and Behavior 2012 May 15.<\/li><li>Outcomes after reinitiating antiretroviral therapy in children randomized to planned treatment interruptions in the PENTA 11 Study. AIDS. 2013 Feb 20;27(4):579-89.AIDS. 2013 Feb 20;27(4):579-89.<\/li><\/ol>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\t\t\t\tThis is a long term follow-up study assessing whether children with HIV infection undergoing planned ART interruptions are disadvantaged clinically, immunologically, virologically or neurologically from periods of time off ART. \t\t<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[],"class_list":["post-2291","post","type-post","status-publish","format-standard","hentry","category-studies"],"_links":{"self":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts\/2291","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/comments?post=2291"}],"version-history":[{"count":0,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts\/2291\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/media?parent=2291"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/categories?post=2291"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/tags?post=2291"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}