{"id":2470,"date":"1998-12-31T00:00:21","date_gmt":"1998-12-30T17:00:21","guid":{"rendered":"https:\/\/www.hivnat.org\/en\/?p=2470"},"modified":"1998-12-31T00:00:21","modified_gmt":"1998-12-30T17:00:21","slug":"a-randomized-open-label-follow-up-study-to-protocol-hiv-nat-003-to-explore-the-antiviral-efficacy-and-tolerability-of-immediate-switching-to-therapy-with-d4t-ddi-versus-continued-azt-3tc-and-deferre","status":"publish","type":"post","link":"https:\/\/www.hivnat.org\/en\/studies\/2470\/","title":{"rendered":"A randomized, open-label, follow-up study to protocol HIV-NAT 003 to explore the antiviral efficacy and tolerability of immediate switching to therapy with d4T\/ddI versus continued AZT\/3TC and deferred switching to d4T\/ddI in a population pretreated with AZT\/3TC for at least 48 weeks and comparing these strategies with immediate switching to therapy with d4T\/3TC\/Abacavir versus continued AZT\/3TC\/ddI and deferred switching to d4T\/3TC\/Aacavir in a population pretreated with AZT\/3TC\/ddI for at least 48 weeks"},"content":{"rendered":"\n\t\t\t\t\n<p><strong>Project no.:<\/strong> HIV-NAT 003.1<\/p>\n\n\n\n<p><strong>Study Objectives:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>To explore the antiretroviral efficacy and tolerability of therapy with d4T\/ddI in patients pretreated with AZT\/3TC and therapy with d4T\/3TC\/Abacavir in patients pretreated with AZT\/3TC\/ddI for at least 48 weeks<\/li><li>To access whether the switching of combination antiretroviral therapy before treatment failure is apparent (immediate switching) results in better virological and\/or immunological responses then switching once treatment failure has become apparent (delayed switching)<\/li><li>To explore the degree and duration of antiretroviral activity of double amd triple nucleoside combinations of AZT\/3TC and AZT\/3TC\/ddI <\/li><\/ul>\n\n\n\n<p><strong>Study Design:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>101 patients entered this study<\/li><li>7 patients were failing therapy at the commencement of study and were switched immediately from AZT\/3TC to d4T\/ddI or from AZT\/3TC\/ddI to d4T\/3TC\/Abacavir<\/li><li>The remaining 97 patients were re-randomized as follow:<ul><li>Immediate or deferred switching from AZT\/3TC to d4T\/ddI<\/li><li>Immediate or deferred switching from AZT\/3TC\/ddI to d4T\/3TC\/Abacavir<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Result:<\/strong> Pending<\/p>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\t\t\t\tTo explore the antiretroviral efficacy and tolerability of therapy with d4T\/ddI in patients pretreated with AZT\/3TC and therapy with d4T\/3TC\/Abacavir in patients pretreated with AZT\/3TC\/ddI for at least 48 weeks\t\t<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[],"class_list":["post-2470","post","type-post","status-publish","format-standard","hentry","category-studies"],"_links":{"self":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts\/2470","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/comments?post=2470"}],"version-history":[{"count":0,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts\/2470\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/media?parent=2470"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/categories?post=2470"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/tags?post=2470"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}