{"id":3375,"date":"2022-03-30T10:18:00","date_gmt":"2022-03-30T03:18:00","guid":{"rendered":"https:\/\/www.hivnat.org\/en\/?p=3375"},"modified":"2022-03-30T10:18:02","modified_gmt":"2022-03-30T03:18:02","slug":"protecting-households-on-exposure-to-newly-diagnosed-index-multidrug-resistant-tuberculosis-patients-phoenix-mdr-tb","status":"publish","type":"post","link":"https:\/\/www.hivnat.org\/en\/studies\/3375\/","title":{"rendered":"Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients (PHOENIx MDR-TB)"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">A Phase 3, open-label, multicenter trial with a cluster-randomized superiority design (eligible contacts in the same household [HH] are a cluster), to compare the efficacy and safety of 26 weeks of Delamanid (DLM) versus 26 weeks of isoniazid (INH) for preventing confirmed or probable active TB during 96 weeks of follow-up among high-risk household contacts (HHCs) of adults with multidrug-resistant tuberculosis (MDR-TB). High-risk HHCs are those with HIV or non-HIV immunosuppression, latent TB infection, and young children below the age of 5 years. Each site will have a run-in phase, where the site will demonstrate feasibility to identify adults with MDR-TB (index cases), access their HHs, screen HHCs, and enroll and follow eligible HHCs.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A Phase 3, open-label, multicenter trial with a cluster-randomized superiority design (eligible contacts in the same household [HH] are a cluster), to compare the efficacy and safety of 26 weeks&hellip; <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[],"class_list":["post-3375","post","type-post","status-publish","format-standard","hentry","category-studies"],"_links":{"self":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts\/3375","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/comments?post=3375"}],"version-history":[{"count":1,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts\/3375\/revisions"}],"predecessor-version":[{"id":3376,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/posts\/3375\/revisions\/3376"}],"wp:attachment":[{"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/media?parent=3375"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/categories?post=3375"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hivnat.org\/en\/wp-json\/wp\/v2\/tags?post=3375"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}