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Home > Studies > 2013
Overview of HIV-NAT Studies
In 2013, HIV-NAT conducted a total of 82 studies, 46 of which were conducted in adults and 36 in children/adolescents. There are 6 pharmacokinetic studies of which 3 are done in children and 3 in adults. There are 13 HIV co-infection and HIV studies: 7 hepatitis studies, 4 influenza studies, 1 human papillloma virus (HPV) and 1 syphilis studies. Out of the 7 hepatitis studies, 4 are done in adults and 3 in the pediatric population. All of the pediatric co-viral studies were opened this year. As for the tuberculosis studies, there are a total of 6 studies of which all are done in adults. 5 are ongoing. There are 7 cohort studies of which 4 are done in adults and 3 in a pediatric population. All cohort studies are ongoing. From the 21 strategic studies, 10 are done in adults and 11 are done in the pediatric population. 9 are ongoing studies whereas 4 have closed this year. A total of 8 new strategic studies were opened this year and are recruiting patients. At the time of writing this, there were 10 studies in the pipeline of which 1 is from the Clinical Research Nurses Department to investigate the association between smoking and recovery of the immune system among HIV-infected adults. Three new studies will target HIV prevention; one new study will use Treatment as Prevention (TasP) targeting IDUs with the WHO Regional Office for the Western Pacific and the Kirby Institute; the other study will Seek, Test and Treat all IDUs for HIV, HCV and HBV as well as TB which will be done with Population Services International (PSI) Thailand, TREAT Asia and the GI department, Faculty of Medicine, Chulalongkorn University whereas the other will be done with the TRCARC to investigate the use of HIV chemoprophylaxis among MSMs. There are also 3 new sexual health studies of which 2 will be done in HIV-infected adolescents and 1 in HIV-infected menopausal women. One of the studies will be done with TREAT Asia to investigate STI interventions among perinatally and behaviorally HIV-infected adolescents whereas the other is still searching for funding and will assess the metabolic outcomes among those using different types of hormonal contraception. At the time of writing this, one of the studies known as the SWITCH study will open at the end of November 2013. This study is done with AIGHD to investigate 3 different treatment regimens and their effects. The other study will assess the quality of generic brands used in governmental hospitals to assure the public that medications used in Thailand are comparable to branded medications whereas another study will characterize the neovagina in an effort to improve transgender health outcomes. Aside from that, HIV-NAT will work with TRCARC and the Chulalongkorn Hospital to set up the Transgender Health Centre which will be the first in the country and the region. Currently TRCARC is the only place in the region and Thailand that offers anal pap smear. In addition, our long-awaited HCV treatment study to compare short-course to the standard course will open at the end of this year.
Number of studies in 2012 vs 2013
Key to abbreviations
PKPharmacokinetics Studies
Viral coinf.Clinical Research Programs in Co-Viral and Viral Infections
TBClinical Research Programs in HIV/TB Co-Infections
CohortLong Term Cohort Analysis
StrategyStrategy Studies
New DrugNew Drug Development
EAPExpanded Access Programs
SexSexual Health Studies
PedPediatric and Youth Research Programs
Please note that this year, each substudy is not counted as a study. Instead, the main study is counted. For example, the START study (Strategic study) has 10 substudies but is counted as only 1 study. In addition, this year we have fewer large studies but more substudies.
Aside from research studies, our staff have been extremely busy submitting abstracts to international conferences, scholarships for additional training, working on their PhD, and working on internal projects to improve the working capacity of their department. Three of our physicians, Dr. Anchalee Avihingsanon, Dr. Reshmie Ramautarsing and Dr. Nadia Kancheva Landolt completed their PhD early this year in the Netherlands. Also, Dr. Wasana Prasitsuebsai was awarded a Data Safety Monitoring Board Fellowship and scholarship to attend the 34th Annual Meeting of the Society of Clinical Trials in Boston in the middle of this year. Upon her return, working with the MRCT Center at Harvard, she has set up a pre-conference, invitation-only DSMB workshop which will launch early in 2014. In addition, our youngest investigator, Dr. Vorapot Sapsirisavat, was awarded the 2014 amfAR HIV scholarship training program in HIV prevention research for MSM in developing countries. He will attend the course at University of Pittsburg from Jan 1-May 31, 2014. Besides the physicians, one of our nurses, Ms. Chuleeporn Wongvoranet, was awarded an HIV Trust Research Scholarship to take a short training course in Qualitative Research Methodology programs at the Health Experiences Research Group in the Department of Primary Healthcare at the University of Oxford, UK. She will help the nurses department launch more sexual health and psychosocial studies.
Under the support and mentor of HIV-NAT’s physicians, several of our staff from the nurses department, CRA department, and Biostatistics department submitted their abstracts to the 5th International Workshop on HIV Pediatrics (28-29 June 2013, Kuala Lumpur, Malaysia) and the 7th IAS Conference on HIV Pathogenesis, Treatment and Prevention (30 June-3 July 2013, Kuala Lumpur, Malaysia). More information can be found at the Presentations at Conferences and Meetings section of this report.
This year, the IT & Data Management Department have revamped their department and the electronic data management system for the whole organization. First, the department is now divided into 3 parts: 1. IT, 2. Data and 3. Cohort. In the middle of this year, both Mr. Chavalun Ruengpanyathip and Mr. Noppong Hirunwadee joined the journal club to present manuscripts related to data management and IT issues. Aside from that, the department has also set up its own journal club for its staff to present relevant information and provide updated information in their field. The department has also set up a new email system allowing all HIV-NAT staff to access email outside of the office. Currently, the department is developing the Electronic Data Capture (EDC) system which is expected to launch in the middle of next year. This new system will generate automatic queries for the data and CRA teams.
Overall Thai Support
Government agenciesnumber of studies
Commission of Higher Education, Ministry of Education (CHE)1
National Research University Grant (NRU)1
Ministry of Public Health (MOPH)2
National Health Security Office (NHSO)6
National Research Council of Thailand (NRCT)5
Thai Medical Schools Consortium (MedResNet)1
Social Security Office (SSO)1
Government Pharmaceutical Organization (GPO)2
Department Disease Control (DDC)3
Academic organizations
Ratchadaphiseksomphot Fund, Faculty of Medicine, Chulalongkorn University7
Research organizations
Thai Red Cross AIDS Research Centre1
Overall International Support
Government agenciesnumber of studies
National Institute of Health (NIH)8
The National Health and Medical Research Council (NHRMC)1
Pharmaceutical partners
Bristol-Myers Squibb3
Gilead Sciences10
Merck & Co., Inc1
ROCHE Pharmaceutical1
Tibotec Pharmaceuticals5
Mylan Laboratories, Inc1
Academic organizations
Foundations for AIDS Research, United States (amfAR)/TREAT Asia17
The Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia5
Alfred Hospital1
Research organization
Pediatric European Network for Treatment of AIDS (PENTA)3
Funding agency
The Aligning Care and Prevention of HIV/AIDS with Government Decentralization to Achieve Coverage and Impact: ACHIEVED Project (Global fund Thailand)3
Bill & Melinda Gates Foundation1
Art AIDS Fund1
Born to Live Charity1
Living & Loving Charity1
The HIV Netherland Australia Thailand Research Collaboration
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