Project no.: HIV-NAT 125/HCV
This is a cross-sectional study that will assess the HCV genotype and gene interleukin 28 (IL-28) in Thai HIV/HCV co-infected patients.
Results: HCV genotype 3 (47%) is predominant circulating HCV genotypes in our HIV/HCV co-infection and HCV mono infection, following by genotype 1 (34%) and genotype 6 (18%). High prevalence of HCV genotype 6 was observed (13% HIV/HCV and 18% HCV mono). HCV genotype 6 tended to have higher HCV RNA but lesser liver fibrosis compared to HCV genotype 1 and 3. Approximately, 91% of our patients have favorable IL-28B gene. Factors associated with moderate to severe liver fibrosis in our HCV patients were HIV-coinfection, HCV genotype 3 and Fib-4 > 1.45
Presentation: Avihingsanon A, Mek-A-nantawat W, Apornpong T, Akkarathamrongsin S, Ubolyam S, Chomhong P, Tangkitvanich P. Distribution of HCV genotype and Single Nucleotide Polymorphisms (SNPs) of IL-28B gene in HIV/HCV coinfected Thai Populations. [Poster # P132] presented at the International Congress on Drug Therapy in HIV. Glasgow, Glasgow, UK. 11-15 November 2012.
Publication: J Gastroenterol Hepatol. 2014 Sep;29(9):1706-14.
